Treatment for Erectile Dysfunction

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ED can have many causes, both psychological and physical. ED from physical causes is fairly common in men as they age.

Sildenafil vs Tadalafil for Erectile Dysfunction

A., Blasetto, J. W., & STELLAR Study Group (2003). Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial). The American Journal of Cardiology, 92(2), 152–160. Erectile dysfunction (ED), also called impotence, can affect your quality of life by decreasing your satisfaction from sex. Medications are available that can help treat ED for many men. The most well-known ED medications include: These prescription drugs increase the levels of nitric oxide in your blood.

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Nitric oxide is a vasodilator, meaning it makes your blood vessels widen to help increase the blood flow. These drugs are especially effective at widening the blood vessels in your penis. More blood in your penis makes it much easier for you to get and maintain an erection when you are sexually aroused. However, these drugs can also cause side some effects. Here are seven of the most common side effects from ED medications.

Watch what you eat when you take your pill.

Some medications can cause ED, and if you’re taking them electively — like finasteride for hair loss — you might want to consider alternatives.23 In finasteride’s case, things like cenforce 100mg tablet minoxidil and laser treatments may prove just as effective without the sexual side effects. Regardless of your ED status, these are mostly all positive adjustments any man can make to improve their life and health. None of them should interfere with your ability to also use prescription interventions to help with your ED. Over time, you may find that these changes allow you to achieve an erection without medical help, but you can utilize prescriptions from Hims in the meantime. Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles.

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Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Physical Activity to Improve Erectile Function: A Systematic Review of Intervention Studies. Avanafil for erectile dysfunction in elderly and younger adults: differential pharmacology and clinical utility. Therapeutics and Clinical Risk Management, 10, 701-711. Visual Side Effects Linked to Sildenafil Consumption: An Update.

What is the role of testosterone therapy in the treatment of erectile dysfunction?

Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors. Sildenafil for Male Erectile Dysfunction: A Systematic Review and Meta-analysis. Cardiac safety in clinical trials of phosphodiesterase 5 inhibitors. The American Journal of Cardiology, 96(12B), 37M–41M. PDE5 inhibitors – pharmacology and clinical applications 20 years after sildenafil discovery. Headaches are the most common side effect associated with ED medications. The sudden change in blood flow from the increased levels of nitric oxide causes the headaches. This side effect is common with all forms of ED medications, so switching brands won’t necessarily alleviate your symptoms. If you have headaches from your ED drug, talk with your doctor about how to prevent them. Some people have muscle aches and pains throughout their bodies while taking ED medications.

Non-medical use

Cui H, Liu B, Song Z, Fang J, Deng Y, Zhang S, Wang H, Wang Z. Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Jenkins, L. C., Gonzalez, J., Tal, R., Guhring, P., Parker, M., & Mulhall, J. P.

Be physically active

(2019). Compliance with Fluoxetine Use in Men with Primary Premature Ejaculation. The Journal of Sexual Medicine, 16(12), 1895. Persistent sexual side effects of finasteride for male pattern hair loss. The Journal of Sexual Medicine, 8(6), 1747–1753.

Important points

Double-blind study of the efficacy and safety of sertraline versus fluoxetine in major depression. International Clinical Psychopharmacology, 8(3), 197–202. Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients. Journal of the American Academy of Dermatology, 84(6), 1644–1651. Jones, P. Others have reported specific pain in their lower back. If you have these types of pain while taking ED medication, over-the-counter (OTC) pain medication may help. However, you should talk with your doctor about other possible causes of your pain.

Country Approved Brands Over-the-counter Availability Prescription Needed Market Share (%) (approximate) Notes
USA Viagra, Cialis, Levitra No Yes 70% Widely prescribed, high brand recognition
Europe Viagra, Cialis, Levitra No Yes 65% Various generics available
India Generic versions available Yes Varies 40% Increased OTC options
Australia Viagra, Cialis No Yes 55% Strict prescription controls

Your doctor can help you choose an OTC medication that is safe to take with your ED medications and with any other medications you take. Your ED medication may cause uncomfortable digestive system side effects. The most common are indigestion and diarrhea.

Better erections, coming up.

H., Davidson, M. H., Stein, E. A., Bays, H. E., McKenney, J. M., Miller, E., Cain, V. To help relieve minor problems, consider making dietary changes to reduce upset stomach. Drinking water instead of caffeinated beverages, alcohol, or juice may help. If changing your diet doesn’t work, talk with your doctor about OTC remedies that may help. An increase in nitric oxide can cause some men to become dizzy.

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British Journal of Pharmacology, 175(13), 2554-2565. Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clinical Interventions in Aging, 1(4), 403-414. Determining the earliest time within 30 minutes to erectogenic effect after tadalafil 10 and 20 mg: a multicenter, randomized, double-blind, placebo-controlled, at-home study.

Oral medications

The Journal of Sexual Medicine, 1(2), 193–200. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases. The Journal of Sexual Medicine, 13(5), 860. Avanafil for treatment of erectile dysfunction: review of its potential.

Best overall: Viagra (sildenafil)

Vascular Health and Risk Management, 8, 517-523. Kumar, M., Pathade, A.D., Gupta, S.V., Goyal, S., Rath, D., Thakre, M., Sanmukhani, J. and Mittal, R. (2022), Efficacy and safety of avanafil as compared with sildenafil in the treatment of erectile dysfunction: A randomized, double blind, multicenter clinical trial. The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. The dizziness caused by ED medications is generally mild. However, any dizziness can cause discomfort during everyday activities.

In rare cases, dizziness from ED medications has led to fainting, which can become a serious health issue.

Traditional ED Medications

The Journal of Sexual Medicine, 16(2), 223–234. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. Indian Journal of Psychological Medicine, 34(3), 255-262. Zinc status and serum testosterone levels of healthy adults.

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Nutrition (Burbank, Los Angeles County, Calif.), 12(5), 344–348. Effect of Vitamin D Supplementation on Testosterone Levels in Men. Hormone and Metabolic Research, 43(3): 223-5. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reproductive Biology and Endocrinology: RB&E, 7, 120.

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The science of vacuum erectile device in penile rehabilitation after radical prostatectomy. Translational Andrology and Urology, 2(1), 61-66. Atallah, S., Haydar, A., Jabbour, T., Kfoury, P., & Sader, G. (2021) The effectiveness of psychological interventions alone, or in combination with phosphodiesterase-5 inhibitors, for the treatment of erectile dysfunction: A systematic review. Indian Dermatology Online Journal, 3(1), 62-65. You should tell your doctor if you experience dizziness while taking ED medications. If you faint while taking these medications, see your doctor right away. ED medications can change the way you see things — literally. They can temporarily alter your eyesight and even cause blurry vision. ED medications aren’t recommended if you have had vision loss, or a retinal disorder called retinitis pigmentosa. A complete loss of vision or changes that don’t go away can signify a more serious issue with your ED medication. Seek emergency medical care if you experience these symptoms. Flushes are temporary periods of redness of the skin. Flushes usually develop on your face and may also spread to parts of your body. Flushes can be mild, like blotchy skin, or severe, like rashes.

Drug Absorption Time Peak Plasma Levels Bioavailability Metabolism Elimination Half-life
Sildenafil 30-120 min 1 hour 41% Liver (CYP3A4) ~4 hours
Tadalafil 30-120 min 2 hours 36% Liver (CYP3A4) ~17.5 hours
Vardenafil 30-60 min 1 hour 15% Liver (CYP3A4) ~4-5 hours
Avanafil 15-30 min 30 minutes 13% Liver (CYP3A4) ~6 hours

Although the appearance may make you uncomfortable, flushes typically aren’t harmful.

Flushes from ED medications may get worse when you: Congestion or a runny or stuffy nose can be a common symptom of ED medications. In most cases, these side effects go away without treatment. Talk with your doctor if they persist.

Drug Mechanism of Action Receptor Target Effect Duration Additional Effects
Sildenafil PDE5 inhibitor, increases blood flow to the penis PDE5 4-6 hours Vasodilation, slight hypotension
Tadalafil PDE5 inhibitor, longer half-life PDE5 Up to 36 hours Smooth muscle relaxation
Vardenafil PDE5 inhibitor, similar to sildenafil PDE5 4-5 hours Minimal effects on blood pressure
Avanafil PDE5 inhibitor, fast-acting PDE5 6 hours Fewer visual side effects

Minor side effects are common when taking ED medication. Still, there are a few side effects that aren’t as common, and some can even be dangerous. Severe side effects of ED medications can include: priapism (erections that last longer than 4 hours) If you have concerns about ED, it’s important to talk with your doctor. Not only is this common condition treatable, but ED may also be an early sign of an underlying medical problem. Sometimes, treating the underlying cause may also help alleviate ED. Talk with your doctor if you are at risk of developing, or currently have, the following conditions: Additionally, ED is more common after the age of 50 and in those who smoke and drink alcohol. You can talk with your doctor about such risk factors and whether ED treatments are appropriate for your situation. When discussing ED treatment with your doctor, it’s important to tell them about all drugs you take and other health conditions you have. If medications aren’t right for your ED, your doctor may suggest other treatment options, such as surgery or vacuum pumps.

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